阿賊Lab

讓你度估的感冒藥
抗組織胺的藥物會因病情的不同，其藥物也有好幾種，因為光是組織胺的接受器目前為止就發現4型，也有作用在影響組織胺生合成的部分。
現在的醫生也會依照病人的需求開給他2.3代的抗組織藥物，比起第一代嗜睡的情況已經改善很多，但是有些paper也指出2,3代的藥物還是有一定得機率通過血腦屏障影響中樞神經，過多的劑量也是會有嗜睡的風險，建議吃藥時還是不要從事需要高度專注的工作喔!

如果對我的內容有意見的或是要補充點資料歡迎跟我討論啊!!!

(這次光是查資料花的時間比畫的還多.....(眼神已死)

註1:拮抗劑(antagonist)指某一類物質會與其受體(或接受器)結合，但不具備活化其受體功能
註2:血腦屏障(blood–brain barrier (BBB)，指在生物體內腦袋與血管之間由內皮細胞（endothelial cells）排列而成，其細胞之間有著間隙選擇性地或是阻止某些物質由血進入腦

資料來源:

l   Saper C.B., Chou T.C., et al. (2001).” The sleep switch: hypothalamic control of sleep and wakefulness.” Trends Neurosci. 24(12):726-31.

l   del Cuvillo A, Mullol J., et al. (2006).” Comparative pharmacology of the H1 antihistamines.” J Investig Allergol Clin Immunol. 16 Suppl 1:3-12.

l   Benarroch E.E. (2010).” Histamine in the CNS: multiple functions and potential neurologic implications.” Neurology. 75(16):1472-9

l   Ramaekers J.G. and Vermeeren A. (2000). ” All antihistamines cross blood-brain barrier.” BMJ. 321(7260):572.

l   Zeitzer J.M. (2013). “Control of sleep and wakefulness in health and disease.” Prog Mol Biol Transl Sci. 119:137-54

l   Walsh G.M., Annunziato L., et al. (2001). “New insights into the second generation antihistamines.” Drugs. 61(2):207-36.

l   Criado P.R., Criado R.F., et al. (2010). “Histamine, histamine receptors and antihistamines: new concepts.” An Bras Dermatol. 85(2):195-210.

l   Pardridge W.M. (2005). “The blood-brain barrier: bottleneck in brain drug development.” NeuroRx. 2(1):3-14.

l   Haas H. and Panula P. (2003). “The role of histamine and the tuberomamillary nucleus in the nervous system.” Nat Rev Neurosci. 4(2):121-30.

l   Thurmond R.L., Gelfand E.W., et al. (2008). “

l   The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.” Nat Rev Drug Discov. 7(1):41-53

l   https://www.youtube.com/watch?v=_e60_4ZV0zs